Renal Impairment: Acute renal failure and worsening of Serious renal failure, which can often require hemodialysis, happen to be documented, typically in association with nausea, vomiting, diarrhea, or dehydration. Use caution when initiating or escalating doses of Saxenda® in sufferers with renal impairmentObserve Intently (one)etonogestrel dec